❓What's the Difference?

Loxoprofen (Loxonin), Celecoxib (Celebrex), and Diclofenac (Voltaren) are all NSAIDs (non-steroidal anti-inflammatory drugs) — a type of pain reliever.
They all reduce inflammation and ease pain, but they differ in strength, stomach side effects, and which conditions they work best for.
Choosing the right one based on your pain type and health condition is important.
Always consult your doctor rather than choosing on your own.

⚙️How to Choose a Pain Reliever

1

Choose by pain severity

Diclofenac for severe pain, Loxoprofen for moderate, Celecoxib for milder pain

2

Choose by duration of use

Short-term: Diclofenac or Loxoprofen. Celecoxib is easier to use for longer periods, but should not be continued indefinitely -- only for as long as needed

3

Choose by stomach sensitivity

If you have a sensitive stomach, Celecoxib (relatively less burden on the stomach) may suit you better

4

Choose by the cause of pain

Acute inflammation: Diclofenac. Chronic joint pain: Celecoxib works well

🔍Which Medication for Which Situation?

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Severe acute low back pain → Diclofenac

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Headache, toothache, period pain → Loxoprofen

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Chronic knee pain → Celecoxib

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Sensitive stomach but need pain relief → Celecoxib

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Need fast relief → Diclofenac or Loxoprofen (works in 30–60 minutes)

💊Key Features of Each Medication

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Diclofenac (Voltaren)

Strong and fast-acting. Best for severe pain and swelling. Hard on the stomach and kidneys — use short-term only

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Loxoprofen (Loxonin)

Well-balanced pain reliever. Works for a wide range of pain. Most commonly prescribed. Best taken with a stomach protector

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Celecoxib (Celebrex)

Relatively less burden on the stomach. However, the package insert carries a boxed warning that celecoxib may increase the risk of serious cardiovascular thrombotic events (heart attack, stroke), and that this risk may increase with duration of use. Do not continue it indefinitely -- use it only for as long as needed. The burden on the kidneys remains the same as with other NSAIDs

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Acetaminophen (Different Class)

Not an NSAID. Weaker against inflammation but places relatively less burden on the stomach. Often used for older adults and pregnant women

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Topical Patches

For those who prefer not to take pills. Applied directly to the painful area. Ketoprofen patches (e.g. Mohrus Tape) can cause photosensitivity: keep the area covered from sunlight while using them and for at least 4 weeks after removal, whatever the weather. They must not be used if you have had photosensitivity to them, have aspirin-induced asthma, or are in late pregnancy

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Rehabilitation (Root Cause)

Pain relievers only manage symptoms. Rehabilitation and lifestyle changes are essential for lasting improvement

📈Summary

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Matching the right medication to your pain type matters

Everyone responds differently to pain medications. Rather than self-medicating with over-the-counter drugs long-term, consult your doctor to find what works best for you. Use medication to manage symptoms while addressing the root cause through rehabilitation.

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Important Safety Notes About NSAIDs
NSAIDs can cause stomach ulcers, kidney problems, and cardiovascular risks. Diclofenac and Loxoprofen are particularly hard on the stomach — consider taking them with a stomach protector. If long-term use is needed, regular blood tests are recommended. NSAIDs must not be used if you have a peptic ulcer, if you have ever had an asthma attack triggered by a painkiller (aspirin-induced asthma), or if you are in late pregnancy.

🏥Not Sure Which Pain Reliever to Use?

Comparing NSAIDs: Loxoprofen, Celecoxib & Diclofenac

Matching the right medication to your pain type matters

💡 Quick Guide

🩻 Gotokuji Orthopedic Clinic