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🏥 Gotokuji Orthopedic Clinic / Patient Guide

How to Take Loxonin Correctly

Loxonin Usage Guide
Know the right timing, intervals, and daily limits

Loxonin (loxoprofen) is one of the most commonly prescribed painkillers in orthopedic care.
It is an NSAID (non-steroidal anti-inflammatory drug) that reduces inflammation and relieves pain, with effects starting in 30 minutes to 1 hour.
The effect lasts about 4 to 6 hours.
By following the correct instructions, you can control pain effectively while keeping side effects to a minimum.

1
Take 60 mg (1 tablet) after meals

Avoid taking it on an empty stomach. Take it after eating or right after a meal to reduce stomach irritation

2
Wait at least 4 hours between doses

Always wait a minimum of 4 hours after the previous dose before taking the next one

3
180 mg (3 tablets) per day is the usual guide

Do not increase the dose on your own; follow your doctor's instructions on how to take it

4
Use only when needed

Long-term continuous use increases the burden on the stomach and kidneys, so take it only when you have pain

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Morning, noon, and evening (after meals): For steady pain control
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Morning and bedtime (every 12 hours): When pain is worse in the morning and at night
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As needed: When you only want to use it when pain strikes
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1 tablet at bedtime: When nighttime pain keeps you from sleeping
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For all patterns, follow these rules: after meals, at least 4 hours apart, max 3 tablets per day
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Always take after meals
Taking it on an empty stomach raises the risk of damaging the stomach lining
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A stomach medicine may be added
If stomach irritation is a concern, a stomach medicine (a PPI or a mucosal protective agent) may be prescribed alongside. Note that this does not protect the kidneys
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Stay well hydrated
Taking it while dehydrated puts extra stress on the kidneys
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Keep use short-term
Taking it for a long time makes stomach ulcers, gastrointestinal bleeding, and strain on the kidneys more likely
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Avoid alcohol
Combining with alcohol greatly increases stomach irritation
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Get regular checkups
If long-term use is needed, have blood tests to monitor kidney function
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A reliable painkiller when used correctly

Loxonin works relatively quickly and can help you keep up with daily life while pain is at its worst. Taking it after meals, spacing doses at least 4 hours apart, and staying within the daily limit are the three basics of using it safely. If you need it for a longer period, talk to your doctor about other options.

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Some people must not take Loxonin, and others need extra caution.
Loxonin must not be used if you have a gastric or duodenal ulcer, or if you have ever had an asthma attack triggered by a painkiller or fever reducer (aspirin-exacerbated respiratory disease). If you have a history of gastritis, reduced kidney function, heart disease or high blood pressure, asthma, or are pregnant (especially in the third trimester), always talk to your doctor before taking it. Loxonin should not be used by children under 15.

💡 4 Rules to Remember

  • Take it after meals. Never take it on an empty stomach
  • Wait at least 4 hours between doses
  • Do not exceed 3 tablets (180 mg) per day
  • If pain lasts more than a week, see your doctor to discuss treating the underlying cause